Author

R. C. Shields

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biophysics· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:ecology & biodiversity· 1 Assay:field survey / ecological data· 1

Frequent Co-Authors

R. A. Burne· 4 shared S. A. M. Underhill· 3 shared S. J. Hagen· 3 shared A. R. Walker· 1 shared A. Reyes· 1 shared B. Chakraborty· 1 shared C. C. Artz· 1 shared J. Kaspar· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersMicrobiology

R. A. Burne

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Repurposing the Streptococcus mutans CRISPR-Cas9 System to Understand Essential Gene Function

R. C. Shields, A. R. Walker, N. Maricic, B. Chakraborty, S. A. Underhill, R. A. Burne

The paper develops a CRISPR interference tool for Streptococcus mutans to study essential genes, identifying growth defects and phenotypes in 77% of targeted strains.

PLOS Pathogens · Mar 9, 2020Peer-reviewedMicrobiology

Carbohydrate and PepO control bimodality in competence development by Streptococcus mutans

S. A. M. Underhill, R. C. Shields, R. A. Burne, S. J. Hagen

This study identifies how carbohydrate source and PepO modulate bimodal comX expression in Streptococcus mutans, revealing mechanisms controlling competence development.

bioRxiv · Jun 13, 2019Biophysics

Long-term fish assemblages of the Ohio River: altered trophic and life history strategies with hydrologic alterations and landuse modifications

M. Pyron, M. Mims, M. M. Minder, R. C. Shields, N. Chodkowski, C. C. Artz

The paper analyzes long-term fish assemblage data from the Ohio River to show changes in taxonomy, trophic structure, and life history strategies linked to hydrologic and land use changes.

bioRxiv · Jan 24, 2019Ecology

Intracellular signaling through the comRS system in Streptococcus mutans genetic competence

S. A. M. Underhill, R. C. Shields, J. R. Kaspar, M. Haider, R. A. Burne, S. J. Hagen

This study shows that S. mutans can activate comX through intracellular positive feedback loops involving ComS/XIP, independent of extracellular signals.

bioRxiv · Aug 22, 2018Microbiology

Intercellular communication via the comX-Inducing Peptide (XIP) of Streptococcus mutans

J. Kaspar, S. A. M. Underhill, R. C. Shields, A. Reyes, S. Rosenzweig, S. J. Hagen, R. A. Burne

This study demonstrates that XIP from Streptococcus mutans functions as an intercellular signal, showing diffusibility and signaling without cell-to-cell contact, with cell lysis enhancing its release.

bioRxiv · Aug 4, 2017Microbiology