Author

J. R. Sedor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:multiome· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. F. O'Toole· 2 shared L. A. Bruggeman· 2 shared S. Madhavan· 2 shared Z. Wu· 2 shared A. L. Hansen· 1 shared D. B. Thomas· 1 shared L. Barisoni· 1 shared L. Luo· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersPathology

J. F. O'Toole

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3 papers

Recent·Most cited

APOL1 is not expressed in proximal tubules and is not filtered

N. A. Blessing, Z. Wu, S. Madhavan, M. K. Shin, M. Hoek, J. R. Sedor, J. F. O'Toole, L. A. Bruggeman

The study examines APOL1 expression in the kidney using transgenic mice and finds it is not expressed in proximal tubules or filtered by them.

PLOS ONE · Jun 17, 2021Peer-reviewedPathology

Towards the NMR solution Structure and the Dynamics of the C-terminal Region of APOL1 and its G1, G2 Variants with a Membrane Mimetic

S. M. Madhavan, A. L. Hansen, S. Cao, J. R. Sedor, M. Buck

This study uses NMR to analyze the structure and dynamics of APOL1 C-terminal regions and their G1, G2 variants, revealing structural changes linked to chronic kidney disease.

bioRxiv · Mar 16, 2021 · PreprintBiophysics

APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy

L. A. Bruggeman, Z. Wu, L. Luo, S. Madhavan, P. E. Drawz, D. B. Thomas, L. Barisoni, J. F. O'Toole, J. R. Sedor

This study shows that APOL1-G0 protects podocytes from HIV-induced damage in mice, while APOL1-G2 does not provide similar protection.

bioRxiv · Apr 18, 2019Pathology