Author

L. A. Bruggeman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. F. O'Toole· 2 shared J. R. Sedor· 2 shared S. Madhavan· 2 shared Z. Wu· 2 shared A. N. Chang· 1 shared A. Naik· 1 shared C. Arana· 1 shared D. B. Thomas· 1 shared

Activity by Year

2019-2024 · peak 1/yr

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10 top collaborators · 20 mutual co-author links

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2 shared papersPathology

J. F. O'Toole

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3 papers

Recent·Most cited

Glomerular Elastic Modulus and Gene Expression PatternsDefine Two Phases of Alport Nephropathy

J. Yoon, Z. Liu, M. Alaba, L. A. Bruggeman, P. Janmey, C. Arana, O. Ayenuyo, I. Medeiros, S. Eddy, M. Kretzler, J. M. Henderson, V. Nair, A. Naik, A. N. Chang, R. T. Miller

This study identifies early glomerular changes and gene expression patterns in Alport syndrome, showing ER stress and four genes as key drivers of disease before proteinuria, and highlights potential therapeutic targets.

bioRxiv · Feb 26, 2024 · PreprintCell Biology

APOL1 is not expressed in proximal tubules and is not filtered

N. A. Blessing, Z. Wu, S. Madhavan, M. K. Shin, M. Hoek, J. R. Sedor, J. F. O'Toole, L. A. Bruggeman

The study examines APOL1 expression in the kidney using transgenic mice and finds it is not expressed in proximal tubules or filtered by them.

PLOS ONE · Jun 17, 2021Peer-reviewedPathology

APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy

L. A. Bruggeman, Z. Wu, L. Luo, S. Madhavan, P. E. Drawz, D. B. Thomas, L. Barisoni, J. F. O'Toole, J. R. Sedor

This study shows that APOL1-G0 protects podocytes from HIV-induced damage in mice, while APOL1-G2 does not provide similar protection.

bioRxiv · Apr 18, 2019Pathology