Author

L. Espinar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

S. Sdelci· 4 shared A. Ganez Zapater· 2 shared A. Ganez-Zapater· 2 shared C. Cannata· 2 shared D. Datta· 2 shared F. Pezzano· 2 shared N. Pardo-Lorente· 2 shared R. Ghose· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersCell Biology

S. Sdelci

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mitochondria-derived nuclear ATP surge protects against confinement-induced proliferation defects

R. Ghose, F. Pezzano, S. Kourtis, I. Sheraj, S. Das, A. Ganez-Zapater, U. Ghose, L. Espinar, K. Parapatics, V. Venturini, A. C. Muller, V. Ruprecht, S. Sdelci

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

bioRxiv · Dec 20, 2023Cell Biology

Adaptation to ARF6-depletion in KRAS-driven PDAC is abolished by targeting TLR2

R. Ghose, S. Das, J. Urgel-Solas, F. Pezzano, D. Datta, U. Ghose, A. Ganez-Zapater, N. Pardo-Lorente, L. Espinar, L. Garcia, C. Cannata, V. Ruprecht, A. Janic, S. Sdelci

This study identifies TLR2 as a target to counteract adaptation to ARF6 depletion in KRAS-driven PDAC, reducing proliferation, migration, and invasion.

bioRxiv · Nov 30, 2023 · PreprintCancer Biology

Nuclear MTHFD2 secures mitosis progression by preserving centromere integrity

N. Pardo-Lorente, A. Gkanogiannis, L. Cozzuto, A. Ganez Zapater, L. Espinar, L. Garcia-Lopez, R. G. Aydin, E. Darai, J. Severino, L. Batlle-Morera, J. Ponomarenko, S. Sdelci

This study shows that nuclear MTHFD2 is essential for mitosis by maintaining centromere integrity and preventing chromosomal abnormalities in cancer cells.

bioRxiv · Jun 1, 2023 · PreprintCell Biology

The BRD4S-LOXL2-MED1 interaction at the forefront of cell cycle transcriptional control in triple-negative breast cancer

L. Pascual-Reguant, T. V. Tian, D. Datta, D. Cianferoni, S. Kourtis, A. Ganez Zapater, C. Cannata, Q. Serra Camprubi, L. Espinar, M. Guirola, J. Querol, A. Miro Canturri, J. Arribas, L. Serrano, S. Peiro, S. Sdelci

This study shows that inhibiting LOXL2 and BRD4 together reduces triple-negative breast cancer proliferation by disrupting the BRD4S-LOXL2-MED1 interaction that controls cell cycle gene expression.

bioRxiv · May 27, 2022 · PreprintCancer Biology

Frequent birth of de novo genes in the compact yeast genome

W. R. Blevins, J. Ruiz-Orera, X. Messeguer, B. Blasco-Moreno, J. L. Villanueva-Canas, L. Espinar, J. Diez, L. Carey, M. M. Alba

This study identifies de novo genes in yeast genomes, showing they arise frequently despite compact genomes and some are translated and under selection.

bioRxiv · Mar 13, 2019 · PreprintEvolutionary Biology