BiochemistrybioRxivPreprint
ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism
B. Rius, J. S. Mesgarzadeh, I. C. Romine…·L. Wiseman
This paper shows that compound 147 reduces amyloidogenic light chain secretion from AL patient plasma cells through PDI modification, independent of ATF6 activation.
DOI 10.1101/2020.05.15.098145