Author

R. J. Paxman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. W. Kelly· 2 shared L. Wiseman· 2 shared B. Rius· 1 shared C.-Y. Lin· 1 shared E. Powers· 1 shared G. M. Kline· 1 shared I. C. Romine· 1 shared J. M. Grandjean· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

J. W. Kelly

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2 papers

Recent·Most cited

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators

G. M. Kline, R. J. Paxman, C.-Y. Lin, N. Madrazo, J. M. Grandjean, K. Lee, K. Nugroho, E. Powers, L. Wiseman, J. W. Kelly

This study shows that AA132, a compound with a 2-amino-p-cresol substructure, globally activates all three UPR arms by covalently modifying ER PDIs, while AA147 selectively activates the ATF6 arm.

bioRxiv · Jan 16, 2023 · PreprintBiochemistry

ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism

B. Rius, J. S. Mesgarzadeh, I. C. Romine, R. J. Paxman, J. W. Kelly, L. Wiseman

This paper shows that compound 147 reduces amyloidogenic light chain secretion from AL patient plasma cells through PDI modification, independent of ATF6 activation.

bioRxiv · May 15, 2020 · PreprintBiochemistry