Author

I. C. Romine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. W. Kelly· 2 shared L. Wiseman· 2 shared B. Rius· 1 shared E. M. Smith-Cohen· 1 shared J. C. Genereux· 1 shared J. M. Grandjean· 1 shared J. S. Mesgarzadeh· 1 shared J. S. Mezgarzadeh· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

J. W. Kelly

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion Through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

J. S. Mezgarzadeh, I. C. Romine, E. M. Smith-Cohen, J. M. Grandjean, J. W. Kelly, J. C. Genereux, L. Wiseman

This study identifies how ATF6 activation reduces amyloidogenic TTR secretion through ER retention mediated by BiP and PDIA4, independent of redox activity.

bioRxiv · Apr 13, 2022Cell Biology

ER Proteostasis Regulators Reduce Amyloidogenic Light Chain Secretion Through an On-Target, ATF6-Independent Mechanism

B. Rius, J. S. Mesgarzadeh, I. C. Romine, R. J. Paxman, J. W. Kelly, L. Wiseman

This paper shows that compound 147 reduces amyloidogenic light chain secretion from AL patient plasma cells through PDI modification, independent of ATF6 activation.

bioRxiv · May 15, 2020 · PreprintBiochemistry

PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress

R. L. Wiseman, I. C. Romine

This study shows that PERK signaling affects extracellular proteostasis by modulating the secretion of TTR in different conformations during ER stress.

bioRxiv · Sep 17, 2018Biochemistry