Cell BiologybioRxivPreprint
Reconstitution of renal cyst formation in 3D culture reveals a role for AMOT and Yap1 in determining cyst size.
C. D. Wells, K. Lange, A. F. Thompson…·R. L. Bacallao
The paper shows that Cadherin 8 and YAP1 drive cyst initiation and expansion, respectively, in 3D kidney cultures, with AMOTL1 inhibiting expansion.
DOI 10.1101/2022.03.01.482118