Reconstitution of renal cyst formation in 3D culture reveals a role for AMOT and Yap1 in determining cyst size.
C. D. Wells, K. Lange, A. F. Thompson, W. M. Xu, S. G. Clendenon, J. S. Underwood, P. Harris, B.-S. Herbert, J. A. Glazier, A. Wandinger-Ness, R. L. Bacallao
The paper shows that Cadherin 8 and YAP1 drive cyst initiation and expansion, respectively, in 3D kidney cultures, with AMOTL1 inhibiting expansion.
bioRxiv · Mar 1, 2022 · PreprintCell Biology