Author

J. Sa-Pessoa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1

Frequent Co-Authors

A. Dumigan· 4 shared J. A. Bengoechea· 4 shared R. Calderon-Gonzalez· 2 shared A. Kissenpfennig· 1 shared A. Lee· 1 shared C. G. Frank· 1 shared C. O'kane· 1 shared D. F. McAuley· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersMicrobiology

A. Dumigan

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4 papers

Recent·Most cited

In vivo single-cell high-dimensional mass cytometry analysis to track the interaction between Klebsiella pneumoniae and myeloid cells.

R. Calderon-Gonzalez, A. Dumigan, J. sa-Pessoa, A. Kissenpfennig, J. A. Bengoechea

This study uses Bac-CyTOF to analyze immune cell interactions with Klebsiella pneumoniae in mice, revealing changes in immune cell populations and the role of T6SS and STING in infection outcomes.

bioRxiv · Dec 14, 2023 · PreprintMicrobiology

Modelling the gastrointestinal carriage of Klebsiella pneumoniae infections.

R. Calderon-Gonzalez, A. Lee, G. Lopez Campos, S. J. Hancock, J. Sa-Pessoa, A. Dumigan, R. McMullan, E. L. Campbell, J. A. Bengoechea

This paper develops a murine model of Klebsiella pneumoniae gastrointestinal colonisation without tissue dissemination, identifying capsule polysaccharide and type VI secretion system roles in colonisation.

bioRxiv · Oct 3, 2022Microbiology

Klebsiella pneumoniae reduces SUMOylation to limit host defence responses

J. Sa-Pessoa, K. Przybyszewska, F. N. Vasconcelos, A. Dumigan, C. G. Frank, L. Hobley, J. A. Bengoechea

This paper shows Klebsiella pneumoniae reduces SUMOylation in host cells to evade immune responses and promote infection.

mBio · Oct 27, 2020Peer-reviewedMicrobiology

A porcine ex vivo lung perfusion model to investigate bacterial pathogenesis

A. Dumigan, M. Fitzgerald, J. Sa-Pessoa, U. Hamid, C. O'kane, D. F. McAuley, J. A. Bengoechea

This paper develops a porcine ex vivo lung perfusion model to study Klebsiella pneumoniae-induced pneumonia, showing it recapitulates lung injury and immune responses similar to mouse models.

bioRxiv · Jul 19, 2019Microbiology