Author

J. A. Bengoechea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Organism:human· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

A. Dumigan· 6 shared J. sa-Pessoa· 4 shared R. Calderon-Gonzalez· 4 shared J. sa-Pessoa Graca Santos· 3 shared A. B. Janssen· 2 shared A. Kissenpfennig· 2 shared B. Morris· 2 shared G. Mills· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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6 shared papersMicrobiology

A. Dumigan

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10 papers

Recent·Most cited

In vivo single-cell high-dimensional mass cytometry analysis to track the interaction between Klebsiella pneumoniae and myeloid cells.

R. Calderon-Gonzalez, A. Dumigan, J. sa-Pessoa, A. Kissenpfennig, J. A. Bengoechea

This study uses Bac-CyTOF to analyze immune cell interactions with Klebsiella pneumoniae in mice, revealing changes in immune cell populations and the role of T6SS and STING in infection outcomes.

bioRxiv · Dec 14, 2023 · PreprintMicrobiology

A cell-free strategy for profiling intracellular antibiotic sensitivity and resistance

K. Chengan, C. Hind, L. Nagappa, M. E. Wand, T. Hanson, R. M. Escolano, A. Tsaousis, J. A. Bengoechea, J. M. Sutton, C. M. Smales, S. J. Moore

This paper introduces a cell-free platform to profile intracellular antibiotic sensitivity and resistance in K. pneumoniae, showing higher sensitivity for some antibiotic classes and identifying a resistance variant.

bioRxiv · Apr 13, 2023 · PreprintMicrobiology

Modelling the gastrointestinal carriage of Klebsiella pneumoniae infections.

R. Calderon-Gonzalez, A. Lee, G. Lopez Campos, S. J. Hancock, J. Sa-Pessoa, A. Dumigan, R. McMullan, E. L. Campbell, J. A. Bengoechea

This paper develops a murine model of Klebsiella pneumoniae gastrointestinal colonisation without tissue dissemination, identifying capsule polysaccharide and type VI secretion system roles in colonisation.

bioRxiv · Oct 3, 2022Microbiology

In vivo single cell transcriptomics reveals Klebsiella pneumoniae rewiring of lung macrophages to promote infection

A. Dumigan, O. Cappa, B. Morris, J. sa-Pessoa Graca Santos, R. Calderon-Gonzalez, G. Mills, R. Lancaster, D. Simpson, A. Kissenpfennig, J. A. Bengoechea

This study identifies a novel host-pathogen interaction where Klebsiella pneumoniae rewires lung macrophages to promote infection by inducing an M(Kp) polarization state.

bioRxiv · Oct 18, 2021 · PreprintMicrobiology

Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity.

C. Feriotti, J. sa-Pessoa Graca Santos, R. Calderon-Gonzalez, L. Gu, B. Morris, R. Sugisawa, J. L. Insua, M. Carty, A. Dumigan, R. Ingram, A. Kissenpfening, A. G. Bowie, J. A. Bengoechea

This study shows Klebsiella pneumoniae uses SARM1, a host protein, to suppress immune responses via type I IFN signaling, enhancing its survival in macrophages.

bioRxiv · Sep 29, 2021Microbiology

Klebsiella pneumoniae reduces SUMOylation to limit host defence responses

J. Sa-Pessoa, K. Przybyszewska, F. N. Vasconcelos, A. Dumigan, C. G. Frank, L. Hobley, J. A. Bengoechea

This paper shows Klebsiella pneumoniae reduces SUMOylation in host cells to evade immune responses and promote infection.

mBio · Oct 27, 2020Peer-reviewedMicrobiology

In vitro evolution of colistin resistance in the Klebsiella pneumoniae complex follows multiple evolutionary trajectories with variable effects on fitness and virulence characteristics.

A. B. Janssen, D. J. Doorduijn, G. Mills, M. R. C. Rogers, M. Bonten, S. Rooijakkers, R. J. L. Willems, J. A. Bengoechea, W. van Schaik

This study shows that Klebsiella pneumoniae complex strains can develop colistin resistance through multiple evolutionary paths, with variable effects on fitness and virulence.

bioRxiv · May 24, 2020Microbiology

Non-clonal emergence of colistin resistance associated with mutations in the BasRS two component system in Escherichia coli bloodstream isolates

A. B. Janssen, T. L. Bartholomew, N. P. Marciszewska, M. Bonten, R. J. L. Willems, J. A. Bengoechea, W. Schaik

This study identifies mutations in the BasRS two-component system as a novel mechanism of colistin resistance in E. coli bloodstream isolates, independent of plasmid-mediated resistance.

bioRxiv · Feb 13, 2020 · PreprintMicrobiology

A porcine ex vivo lung perfusion model to investigate bacterial pathogenesis

A. Dumigan, M. Fitzgerald, J. Sa-Pessoa, U. Hamid, C. O'kane, D. F. McAuley, J. A. Bengoechea

This paper develops a porcine ex vivo lung perfusion model to study Klebsiella pneumoniae-induced pneumonia, showing it recapitulates lung injury and immune responses similar to mouse models.

bioRxiv · Jul 19, 2019Microbiology

Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent

J. A. Bengoechea, D. Storey, A. Mcnally, M. Astrand, J. sa-Pessoa Graca Santos, I. Rodriguez-Escudero, B. Elmore, L. Palacios, H. Marshall, L. Hobley, M. Molina, V. J. Cid, T. A. Salminen

This study identifies PhoPQ as a regulator of Klebsiella pneumoniae T6SS activity, which mediates microbial competition and is dependent on reactive oxygen species.

bioRxiv · Jul 10, 2019Microbiology