Author

A. Dumigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

J. A. Bengoechea· 6 shared J. sa-Pessoa· 4 shared R. Calderon-Gonzalez· 4 shared A. Kissenpfennig· 2 shared B. Morris· 2 shared J. sa-Pessoa Graca Santos· 2 shared A. G. Bowie· 1 shared A. Kissenpfening· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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6 shared papersMicrobiology

J. A. Bengoechea

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6 papers

Recent·Most cited

In vivo single-cell high-dimensional mass cytometry analysis to track the interaction between Klebsiella pneumoniae and myeloid cells.

R. Calderon-Gonzalez, A. Dumigan, J. sa-Pessoa, A. Kissenpfennig, J. A. Bengoechea

This study uses Bac-CyTOF to analyze immune cell interactions with Klebsiella pneumoniae in mice, revealing changes in immune cell populations and the role of T6SS and STING in infection outcomes.

bioRxiv · Dec 14, 2023 · PreprintMicrobiology

Modelling the gastrointestinal carriage of Klebsiella pneumoniae infections.

R. Calderon-Gonzalez, A. Lee, G. Lopez Campos, S. J. Hancock, J. Sa-Pessoa, A. Dumigan, R. McMullan, E. L. Campbell, J. A. Bengoechea

This paper develops a murine model of Klebsiella pneumoniae gastrointestinal colonisation without tissue dissemination, identifying capsule polysaccharide and type VI secretion system roles in colonisation.

bioRxiv · Oct 3, 2022Microbiology

In vivo single cell transcriptomics reveals Klebsiella pneumoniae rewiring of lung macrophages to promote infection

A. Dumigan, O. Cappa, B. Morris, J. sa-Pessoa Graca Santos, R. Calderon-Gonzalez, G. Mills, R. Lancaster, D. Simpson, A. Kissenpfennig, J. A. Bengoechea

This study identifies a novel host-pathogen interaction where Klebsiella pneumoniae rewires lung macrophages to promote infection by inducing an M(Kp) polarization state.

bioRxiv · Oct 18, 2021 · PreprintMicrobiology

Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity.

C. Feriotti, J. sa-Pessoa Graca Santos, R. Calderon-Gonzalez, L. Gu, B. Morris, R. Sugisawa, J. L. Insua, M. Carty, A. Dumigan, R. Ingram, A. Kissenpfening, A. G. Bowie, J. A. Bengoechea

This study shows Klebsiella pneumoniae uses SARM1, a host protein, to suppress immune responses via type I IFN signaling, enhancing its survival in macrophages.

bioRxiv · Sep 29, 2021Microbiology

Klebsiella pneumoniae reduces SUMOylation to limit host defence responses

J. Sa-Pessoa, K. Przybyszewska, F. N. Vasconcelos, A. Dumigan, C. G. Frank, L. Hobley, J. A. Bengoechea

This paper shows Klebsiella pneumoniae reduces SUMOylation in host cells to evade immune responses and promote infection.

mBio · Oct 27, 2020Peer-reviewedMicrobiology

A porcine ex vivo lung perfusion model to investigate bacterial pathogenesis

A. Dumigan, M. Fitzgerald, J. Sa-Pessoa, U. Hamid, C. O'kane, D. F. McAuley, J. A. Bengoechea

This paper develops a porcine ex vivo lung perfusion model to study Klebsiella pneumoniae-induced pneumonia, showing it recapitulates lung injury and immune responses similar to mouse models.

bioRxiv · Jul 19, 2019Microbiology