Author

J. Sachithanandham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Pekosz· 2 shared B. A. Pinsky· 1 shared C. Guo· 1 shared D. J. Sullivan· 1 shared E. U. Anaya· 1 shared H. H. Mostafa· 1 shared J. Villano· 1 shared M. Craney· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioengineering

A. Pekosz

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2 papers

Recent·Most cited

Antigen-display exosomes provide adjuvant-free protection against SARS-CoV-2 disease at nanogram levels of spike protein

C. Guo, J. Sachithanandham, W. Zhong, M. Craney, J. Villano, A. Pekosz, S. Gould

This study demonstrates that antigen-display exosomes can induce strong neutralizing antibodies and protect against SARS-CoV-2 at nanogram levels of spike protein without adjuvant.

bioRxiv · Jan 4, 2024 · PreprintBioengineering

Convergent Evolution of A-Lineage (Clade 19B) SARS-CoV-2 Spike Sequences with B-Lineage Variants of Concern Affects Virus Replication in a Temperature-Dependent Manner on Human Nasal Epithelial Cell Cultures

S. Yoon, E. U. Anaya, J. Sachithanandham, B. A. Pinsky, D. J. Sullivan, H. H. Mostafa, A. Pekosz

This study shows A-lineage SARS-CoV-2 variants evolved mutations similar to B-lineage VOCs, improving replication in human nasal cells and showing temperature-dependent growth advantages.

bioRxiv · Mar 3, 2023 · PreprintMicrobiology