W. Zhong

Antigen-display exosomes provide adjuvant-free protection against SARS-CoV-2 disease at nanogram levels of spike protein

This study demonstrates that antigen-display exosomes can induce strong neutralizing antibodies and protect against SARS-CoV-2 at nanogram levels of spike protein without adjuvant.

Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection.

This study shows that different growth media affect SARS-CoV-2 susceptibility in human nasal epithelial cultures but not Influenza A, with protease expression playing a role.

Discovery of microsized RNA-derived RNAs and polypeptides in human cells

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

Collagen and actin network mediate antiviral immunity against Orsay in C. elegans intestinal cells

The paper identifies collagens and actin networks as antiviral barriers in C. elegans intestinal cells against Orsay virus.

Colocalization of Protein and microRNA Markers Reveals Unique Extracellular Vesicle Sub-Populations for Early Cancer Detection

This study introduces NOBEL-SPA to analyze EV sub-populations by colocalizing protein and miRNA markers, identifying unique signatures for early breast cancer detection.

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors

This study shows that targeting FAP+CAFs in desmoplastic pancreatic tumors reduces stromal barriers, enhances T cell infiltration, and improves response to immunotherapy.

Adverse outcomes in SARS-CoV-2 infected pregnant mice are gestational age-dependent and resolve with antiviral treatment

This study shows that SARS-CoV-2 infection in pregnant mice causes worse outcomes at later gestational ages, which can be improved with antiviral treatment.

Pathogenesis of Breakthrough Infections with SARS-CoV-2 Variants in Syrian Hamsters

This study investigates SARS-CoV-2 variant pathogenesis in Syrian hamsters, finding that prior infection reduces disease severity upon reinfection with different variants.

Supercharged Protein Nanosheets for Cell Expansion on Bioemulsions

This study shows supercharged proteins can form elastic nanosheets that support cell adhesion and ECM protein adsorption, enabling stem cell expansion on bioemulsions.

CsrA-controlled proteins reveal new dimensions of Acinetobacter baumannii desiccation tolerance

This study identifies CsrA-controlled proteins in A. baumannii that contribute to desiccation tolerance, revealing novel mechanisms involving proteins of unknown function and intrinsically disordered proteins.

A Cyclic Phosphoramidate Prodrug of 2-deoxy-2-fluoro-2-C-methylguanosine for the Treatment of Dengue Infection

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

Potential microenvironment of SARS-CoV-2 infection in airway epithelial cells revealed by Human Protein Atlas database analysis

The paper analyzes the Human Protein Atlas database to identify potential key molecules in the airway epithelial cell microenvironment that may facilitate SARS-CoV-2 entry and immune response activation.

Streptococcus pyogenes Cas9 displays biased one-dimensional diffusion on dsDNA to search for a target

This study shows that Cas9 uses biased one-dimensional diffusion along dsDNA to efficiently locate its target, with diffusion length quantified at 27 bp.

Molecular and cellular phenotypic differences distinguish murine syngeneic models from human tumors

This study identifies molecular and cellular differences between murine syngeneic tumor models and human tumors, highlighting limitations in using syngeneic models for immunotherapy research.

Effect of different forage-to-concentrate ratios on the structure of rumen bacteria and its relationship with nutrition levels and real-time methane production in sheep

This study examines how varying forage-to-concentrate ratios in sheep diets affect rumen bacterial structure, nutrient levels, and methane production, identifying key bacterial genera correlated with these factors.

Molecular basis of P major human rotavirus VP8* domain interactions with histo-blood group antigens

This paper uses NMR to determine how P[8] and P[6] rotavirus VP8* domains bind to different histo-blood group antigens, revealing structural differences that may explain their distinct host ranges and evolutionary adaptations.