Author

J. Villano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 3 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Pekosz· 6 shared R. Zhou· 4 shared A. Braxton· 2 shared A. Jedlicka· 2 shared J. Mankowski· 2 shared K. Mulka· 2 shared M. Craney· 2 shared P. Creisher· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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6 shared papersPathology

A. Pekosz

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19

D. Ashok, T. Liu, J. Criscione, M. Prakash, B. Kim, J. Chow, M. Craney, K. Papanicolaou, A. Sidor, D. B. Foster, A. Pekosz, J. Villano, D.-H. Kim, B. O'Rourke

This study shows that SARS-CoV-2 infection causes persistent cardiac conduction system dysfunction in hamsters, driven by innate immune activation and mitochondrial ROS, with potential implications for long COVID.

bioRxiv · Jan 5, 2024Pathology

Antigen-display exosomes provide adjuvant-free protection against SARS-CoV-2 disease at nanogram levels of spike protein

C. Guo, J. Sachithanandham, W. Zhong, M. Craney, J. Villano, A. Pekosz, S. Gould

This study demonstrates that antigen-display exosomes can induce strong neutralizing antibodies and protect against SARS-CoV-2 at nanogram levels of spike protein without adjuvant.

bioRxiv · Jan 4, 2024 · PreprintBioengineering

Pathogenesis of Breakthrough Infections with SARS-CoV-2 Variants in Syrian Hamsters

J. Plunkard, K. Mulka, R. Zhou, P. Tarwater, W. Zhong, M. Lowman, A. Wong, A. Pekosz, J. Villano

This study investigates SARS-CoV-2 variant pathogenesis in Syrian hamsters, finding that prior infection reduces disease severity upon reinfection with different variants.

bioRxiv · Jan 12, 2023 · PreprintMicrobiology

Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

M. Chen, A. Pekosz, J. Villano, W. Shen, R. Zhou, H. Kulaga, Z. Li, S. E. Beck, K. W. Witwer, J. Mankowski, M. Ramanathan, N. Rowan, A. Lane

This study examines how SARS-CoV-2 variants infect nasal and olfactory tissues, showing differences in tropism, immune response, and regeneration across age groups.

bioRxiv · Apr 12, 2022Pathology

Progression and Resolution of SARS-1 CoV-2 Infection in Golden Syrian Hamsters

K. Mulka, S. Beck, C. Solis, A. Johanson, S. Queen, M. McCarron, M. Richardson, R. Zhou, P. Marinho, A. Jedlicka, S. Guerrero-Martin, E. Shirk, A. Braxton, J. Brockhurst, P. Creisher, , J. Mankowski

This study tracks SARS-CoV-2 infection progression in golden Syrian hamsters, showing weight loss, lung damage, and resolution over time.

bioRxiv · Jun 25, 2021Pathology

Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model

S. Dhakal, C. A. Ruiz-Bedoya, R. Zhou, P. Creisher, J. Villano, K. Littlefield, J. Castillo, P. Marinho, A. Jedlicka, A. Ordonez, N. Majewska, M. Betenbaugh, K. Flavahan, A. Mueller, M. Looney, , S. L. Klein

This study shows that male golden Syrian hamsters experience more severe lung disease and lower antiviral antibody responses compared to females after SARS-CoV-2 infection.

bioRxiv · Apr 2, 2021Microbiology