Exosome-mediated MIR211 modulates tumor microenvironment via the DUSP6-ERK5 axis and contributes to BRAFV600E inhibitor resistance in melanoma.
B. Lee, A. Sahoo, J. Marchica, J. Sawada, S. Sahoo, F. I. A. L. Layng, D. Finlay, J. Mazar, P. Joshi, M. Komatsu, K. Vuori, G. Powis, P. R. de Jong, A. Ray, R. J. Perera
This study shows MIR211 promotes melanoma growth and resistance to BRAF inhibitors by modulating the DUSP6-ERK5 axis via exosome transfer in the tumor microenvironment.
bioRxiv · Feb 13, 2019 · PreprintCancer Biology