M. Komatsu

Variability in radiocesium activity concentration in growing hardwood shoots in Fukushima, Japan

The paper models radiocesium activity concentration variability in hardwood shoots to determine an optimal sample size for accurate estimation.

Mechanistic insights into the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control

This study elucidates the mechanism of the UFM1 E3 ligase complex in ufmylation and its role in ER-RQC by showing its interaction with CDK5RAP3 and ufmylated RPL26.

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response

This study identifies ULK1 as the kinase responsible for phosphorylating p62, which activates NRF2 in a redox-independent manner through retention of KEAP1 in p62 bodies.

Droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show slower inner fluidity

This study investigates how ALS/FTD-related p62 mutations affect liquid droplet properties, finding that some mutants show reduced Nrf2 activation and delayed turnover, while all exhibit slower inner fluidity.

Autophagy controls lipid droplet formation by fine-tuning NCoR1 levels

This study shows autophagy regulates lipid droplet formation by modulating NCoR1 levels, affecting LXR target gene expression and lipid metabolism in the liver.

NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system

This study shows that NBR1 promotes p62-liquid droplet formation, enhancing the Keap1-Nrf2 pathway activation during oxidative stress.

Exosome-mediated MIR211 modulates tumor microenvironment via the DUSP6-ERK5 axis and contributes to BRAFV600E inhibitor resistance in melanoma.

This study shows MIR211 promotes melanoma growth and resistance to BRAF inhibitors by modulating the DUSP6-ERK5 axis via exosome transfer in the tumor microenvironment.