miR-486 is an epigenetic modulator of Duchenne muscular dystrophy pathologies
Rylie M. Hightower, Adrienne Samani, Andrea L. Reid, Katherine G. English, Michael A. Lopez, J. Scott Doyle, Michael J. Conklin, David Alan Schneider, Marcas M. Bamman, Jeffrey J. Widrick, David K. Crossman, Min Xie, David I.H. Jee, Eric C. Lai, Matthew S. Alexander
The paper shows miR-486 is reduced in DMD muscles and its loss causes muscle and cardiac defects, identifying it as a driver of disease and a potential biomarker.
bioRxiv · Jun 14, 2021 · PreprintGenetics