Eric C. Lai

The paper shows that endogenous siRNAs have much broader regulatory effects on host mRNAs in Drosophila simulans testis compared to Drosophila melanogaster.

The paper identifies population-specific alternative polyadenylation (APA) responses to acute ethanol exposure in Drosophila melanogaster, showing genotype- and population-dependent shifts in 3' UTR length.

The paper analyzes RNAi pathway evolution in Drosophila, finding recurrent AGO2 expansion and testis-biased expression of RNAi factors, suggesting a role in sex chromosome conflicts.

The paper analyzes evolutionary divergence in meiotic recombination proteins across four taxa, identifying regions under positive selection and functional constraints using structural and functional data.

This study investigates the effects of a Dicer1 mutation on miRNA function, showing both loss and gain of miRNA activity through strand switching.

The paper investigates the roles of Microprocessor and its cofactors ERH and SAFB1/2 in miRNA cluster assistance, revealing their distinct functional contributions to the process.

This study uses cryo-EM and biochemical analyses to reveal the structural flexibility of the Microprocessor in recognizing and processing different pri-let-7 miRNAs.

The paper identifies miR-QTLs in older adult brains and links four miRNAs to multiple neuropsychiatric and neurodegenerative diseases through integration with GWAS results.

The paper benchmarks 16 circRNA detection tools across three human cell types, finding large differences in sensitivity but consistent precision, and recommends tool combinations for improved detection.

The paper presents an aging Drosophila cell atlas, identifies cell type-specific aging patterns, and shows ribosomal gene expression as a conserved aging predictor.

This study shows that the X-linked miR-506 family miRNAs enhance sperm competitiveness and male reproductive fitness by fine-tuning gene expression during spermatogenesis.

The paper shows miR-486 is reduced in DMD muscles and its loss causes muscle and cardiac defects, identifying it as a driver of disease and a potential biomarker.

The paper shows the Drosophila Exon Junction Complex suppresses cryptic splice sites and prevents faulty mRNA resplicing.

This study investigates the roles of ELAV/Hu RNA binding proteins in neuronal alternative splicing and polyadenylation, showing their overlapping functions in suppressing exons and polyadenylation sites.

The paper identifies a double negative post-transcriptional regulatory circuit involving miR-iab-4/8, Hth, and Dsx that specifies the virgin behavioral state in Drosophila.

The paper shows that miRNA regulation and neural-specific alternative polyadenylation of a single locus control complex behaviors in female flies by modulating homothorax expression.

This study investigates the in vivo functions of BEN-solo proteins in Drosophila embryos, showing they act as insulators to partition active chromatin and regulate gene activation.

CrossBrowse enables visualization of cross-species genomic datasets, revealing insights into functional element conservation and divergence across species.

The paper generates a comprehensive sRNA catalog across 12 Drosophila species to study miRNA diversity, evolution, and functional variation.