A Purinergic Mechanism Underlying Metformin Regulation of Hyperglycemia
J. Senfeld, Q. Peng, Y. Shi, S. Qian, J. Shen
The paper shows metformin reduces high glucose-stimulated ATP secretion, blocking purinergic signaling that causes hepatic insulin resistance and glucose production.
bioRxiv · Sep 27, 2022Pharmacology & Toxicology