Author

J. Sierra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Simon· 1 shared E. H. de Laorden· 1 shared G. Liszczak· 1 shared J. A. Kilgore· 1 shared J. Mohapatra· 1 shared K. Tashiro· 1 shared M. Iglesias· 1 shared M. Mellen· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

D. Simon

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tumor microenvironment noise-induced polarization: the main challenge in macrophages' immunotherapy for cancer.

J. Sierra, U. Avila-Ponce de Leon, P. Padilla-Longoria

This paper investigates how epigenetic noise in the tumor microenvironment drives macrophage polarization, promoting cancer progression, and proposes strategies to enhance immunotherapy effectiveness.

bioRxiv · May 2, 2024Cancer Biology

Human Placenta-Derived Mesenchymal Stem Cells Stimulate Neuronal Regeneration By Promoting Axon Growth And Restoring Neuronal Activity

P. de la Villa, M. T. Moreno, M. Mellen, M. Iglesias, D. Simon, E. H. de Laorden, J. Sierra

This study demonstrates that human placenta-derived mesenchymal stem cells promote axon growth and restore neuronal activity in damaged rat-retina neurons through paracrine mechanisms involving neurotrophic factors.

bioRxiv · Oct 26, 2023 · PreprintCell Biology

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

J. Mohapatra, K. Tashiro, R. L. Beckner, J. Sierra, J. A. Kilgore, N. S. Williams, G. Liszczak

The paper develops a method to install ADP-ribose polymers on proteins and shows that serine ADPr marks nucleosomes for ALC1-dependent chromatin remodeling.

bioRxiv · Jul 6, 2021Biochemistry