Author

N. S. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. A. Kilgore· 2 shared A. B. Desai· 1 shared A. B. Dogan· 1 shared A. R. Frank· 1 shared D. Agac Cobanoglu· 1 shared D. G. McFadden· 1 shared E. S. Welf· 1 shared G. Liszczak· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBioengineering

J. A. Kilgore

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

A. R. Frank, V. Li, S. D. Shelton, J. Kim, G. M. Stott, L. Neckers, Y. Xie, N. S. Williams, P. Mishra, D. G. McFadden

This study shows that mitochondrial complex I defects in thyroid cancer drive reliance on aerobic fermentation, which can be targeted with lactate dehydrogenase inhibitors.

bioRxiv · Aug 16, 2022Cancer Biology

Polymer microparticles prolong delivery of the 15-PGDH inhibitor SW033291

A. B. Dogan, N. A. Rohner, J. N. P. Smith, J. A. Kilgore, N. S. Williams, S. D. Markowitz, H. A. von Recum, A. B. Desai

This paper develops a sustained release platform using β-CD microparticles to extend the delivery of the 15-PGDH inhibitor SW033291 beyond one week.

bioRxiv · Aug 15, 2021Bioengineering

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

J. Mohapatra, K. Tashiro, R. L. Beckner, J. Sierra, J. A. Kilgore, N. S. Williams, G. Liszczak

The paper develops a method to install ADP-ribose polymers on proteins and shows that serine ADPr marks nucleosomes for ALC1-dependent chromatin remodeling.

bioRxiv · Jul 6, 2021Biochemistry

Cancer drug discovery as a low rank tensor completion problem

V. Siruvallur Murali, D. Agac Cobanoglu, M. Hsieh, M. Zinn, V. S. Malladi, J. Gesell, N. S. Williams, E. S. Welf, G. V. Raj, M. C. Cobanoglu

This paper frames cancer drug discovery as a low rank tensor completion problem and identifies novel drug candidates through computational methods and experimental validation.

bioRxiv · Mar 8, 2021 · PreprintCancer Biology