M. Iglesias

Human Placenta-Derived Mesenchymal Stem Cells Stimulate Neuronal Regeneration By Promoting Axon Growth And Restoring Neuronal Activity

This study demonstrates that human placenta-derived mesenchymal stem cells promote axon growth and restore neuronal activity in damaged rat-retina neurons through paracrine mechanisms involving neurotrophic factors.

A Functional Exodermal Suberin is Key for Plant Nutrition and Growth in Potato

This study shows that exodermal suberin in potato roots is crucial for nutrient transport and growth, as its reduction leads to altered mineral concentrations and growth defects.

IKK1 kinase coordinates BRD4 and JAK/STAT signaling to subvert DNA damage-based anticancer therapy

This study identifies IKK1's role in coordinating BRD4 and JAK/STAT signaling to resist DNA damage-based therapy in colorectal cancer.

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion

This study shows that reducing mucin secretion in colorectal cancer cells increases their sensitivity to chemotherapy, offering a strategy to overcome chemoresistance.

Chemotherapy induces a YAP1-dependent fetal conversion to human Colorectal Cancer cells that is predictive of poor patient outcome

The paper shows that sublethal chemotherapy induces a YAP1-dependent fetal phenotype in colorectal cancer cells, which predicts poor patient outcomes.

A short course of Tofacitinib sustains the immunoregulatory effect of CTLA4-Ig in presence of inflammatory cytokines and promotes long-term survival of murine cardiac allografts

This study shows that combining Tofacitinib with CTLA4-Ig improves cardiac allograft survival by reducing effector T cells and increasing regulatory T cells in mice.

Systematic Development Of Sandwich Immunoassays For The Plasma Secretome

The paper develops a workflow to build dual binder sandwich immunoassays for plasma secretome proteins, validating 102 targets and comparing assay performance with other methods.

Type-I interferons inhibit interleukin-10 signaling and favor type 1 diabetes development in NOD mice

This study shows that type-I interferons inhibit IL-10 signaling in T cells, promoting type 1 diabetes in NOD mice by altering T cell responses and spatial localization.