Author

J. Staples-Ager

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Sharrar· 2 shared D. Rabuka· 2 shared L. Arake de Tacca· 2 shared M. Schelle· 2 shared T. Collingwood· 2 shared Z. Meacham· 2 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

A. Sharrar

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Author profile →

2 papers

Recent·Most cited

Discovery and engineering of AiEvo2, a novel Cas12a nuclease for human gene editing applications

A. Sharrar, L. Arake de Tacca, Z. Meacham, J. Staples-Ager, T. Collingwood, D. Rabuka, M. Schelle

This paper identifies and engineers a novel Cas12a nuclease (AiEvo2) with improved specificity and efficacy for human gene editing, including applications in Huntington's disease and CAR-T therapy.

bioRxiv · Aug 28, 2023Biochemistry

μCas, a novel class of miniature type-V Cas12f nucleases with diverse PAM

A. Sharrar, L. Arake de Tacca, T. Collingwood, Z. Meacham, D. Rabuka, J. Staples-Ager, M. Schelle

The paper describes μCas, a new class of small Cas12f nucleases with broader PAM preferences, enabling more genomic editing possibilities.

bioRxiv · Feb 3, 2023 · PreprintBiochemistry