Author

A. Sharrar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:gene regulatory network inference· 3 Assay:metagenomics· 3 Approach:statistical model· 3 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

A. Crits-Christoph· 3 shared J. F. Banfield· 3 shared S. Diamond· 3 shared A. Lavy· 2 shared D. Rabuka· 2 shared J. Staples-Ager· 2 shared K. H. Williams· 2 shared L. Arake de Tacca· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

A. Crits-Christoph

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Discovery and engineering of AiEvo2, a novel Cas12a nuclease for human gene editing applications

A. Sharrar, L. Arake de Tacca, Z. Meacham, J. Staples-Ager, T. Collingwood, D. Rabuka, M. Schelle

This paper identifies and engineers a novel Cas12a nuclease (AiEvo2) with improved specificity and efficacy for human gene editing, including applications in Huntington's disease and CAR-T therapy.

bioRxiv · Aug 28, 2023Biochemistry

μCas, a novel class of miniature type-V Cas12f nucleases with diverse PAM

A. Sharrar, L. Arake de Tacca, T. Collingwood, Z. Meacham, D. Rabuka, J. Staples-Ager, M. Schelle

The paper describes μCas, a new class of small Cas12f nucleases with broader PAM preferences, enabling more genomic editing possibilities.

bioRxiv · Feb 3, 2023 · PreprintBiochemistry

Meanders as a scaling motif for understanding of floodplain soil microbiome and biogeochemical potential at the watershed scale

P. B. Matheus Carnevali, A. Lavy, A. D. Thomas, A. Crits-Christoph, S. Diamond, R. Meeheust, M. R. Olm, A. Sharrar, S. Lei, W. Dong, N. Falco, N. Bouskill, M. Newcomer, P. Nico, H. Wainwright, , J. F. Banfield

The paper investigates microbial metabolic potential in floodplain soils along a river corridor, finding that meander-bound regions predict biogeochemical capacities at the watershed scale.

Microbiome · May 22, 2021Peer-reviewedMicrobiology

Soils and sediments host novel archaea with divergent monooxygenases implicated in ammonia oxidation

S. Diamond, A. Lavy, A. Crits-Christoph, P. B. Matheus Carnevali, A. Sharrar, K. H. Williams, J. F. Banfield

The paper identifies novel archaea in soils and sediments with divergent CuMMO enzymes, suggesting they contribute to nitrogen cycling through ammonia oxidation.

bioRxiv · May 3, 2021 · PreprintMicrobiology

Bacterial secondary metabolite biosynthetic potential in soil varies with phylum, depth, and vegetation type

A. Sharrar, A. Crits-Christoph, R. Meheust, S. Diamond, E. Starr, J. Banfield

The paper examines bacterial secondary metabolite biosynthetic potential in soil, finding variations linked to phylum, depth, and vegetation type.

bioRxiv · Oct 25, 2019Microbiology

Recovery of genomes from metagenomes via a dereplication, aggregation, and scoring strategy

C. M. K. Sieber, A. J. Probst, A. Sharrar, B. C. Thomas, M. Hess, S. G. Tringe, J. F. Banfield

This paper introduces DAS Tool, a metagenomic binning method that improves genome recovery accuracy and completeness across diverse samples.

bioRxiv · Feb 11, 2017Microbiology