Author

L. Arake de Tacca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:protein folding & dynamics· 2 Assay:CRISPR screen· 1 Approach:genetic perturbation / CRISPR· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Rabuka· 3 shared M. Schelle· 3 shared A. Sharrar· 2 shared J. Staples-Ager· 2 shared T. Collingwood· 2 shared Z. Meacham· 2 shared J. Bondy-Denomy· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

D. Rabuka

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Author profile →

3 papers

Recent·Most cited

Discovery and engineering of AiEvo2, a novel Cas12a nuclease for human gene editing applications

A. Sharrar, L. Arake de Tacca, Z. Meacham, J. Staples-Ager, T. Collingwood, D. Rabuka, M. Schelle

This paper identifies and engineers a novel Cas12a nuclease (AiEvo2) with improved specificity and efficacy for human gene editing, including applications in Huntington's disease and CAR-T therapy.

bioRxiv · Aug 28, 2023Biochemistry

Anti-CRISPR protein mediated degradation of Cas9 in human cells

L. Arake de Tacca, J. Bondy-Denomy, D. Rabuka, M. Schelle

This study shows AcrIIA1 induces degradation of SpyCas9 and SauCas9 in human cells, suggesting a mechanism to modulate Cas9 activity for safer gene editing.

bioRxiv · Mar 29, 2023 · PreprintBiochemistry

μCas, a novel class of miniature type-V Cas12f nucleases with diverse PAM

A. Sharrar, L. Arake de Tacca, T. Collingwood, Z. Meacham, D. Rabuka, J. Staples-Ager, M. Schelle

The paper describes μCas, a new class of small Cas12f nucleases with broader PAM preferences, enabling more genomic editing possibilities.

bioRxiv · Feb 3, 2023 · PreprintBiochemistry