Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics
R. P. Wallace, K. C. Refvik, J. T. Antane, K. Brünggel, A. C. Tremain, M. R. Raczy, A. T. Alpar, M. Nguyen, A. Solanki, A. J. Slezak, E. A. Watkins, A. L. Lauterbach, D. S. Wilson, J. A. Hubbell
This study shows that conjugating immunogenic biologics to a synthetic mannose polymer reduces anti-drug antibody responses by impairing T cell and B cell responses.
bioRxiv · Apr 7, 2023Bioengineering