M. Nguyen

LDL-Binding IL-10 Reduces Vascular Inflammation in Atherosclerotic Mice

This paper develops a targeted IL-10 therapy by fusing it with an LDL-binding antibody fragment, showing reduced vascular inflammation in atherosclerotic mice.

Parkinson's genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes

The paper identifies a pyroptotic pathway involving Parkinson's disease proteins and mtDNA trafficking to lysosomes.

Injectable butyrate-prodrug micelles induce long-acting immune modulation and suppress autoimmune arthritis in mice

This study develops butyrate-prodrug micelles that target lymphatics to induce long-term immune modulation and reduce arthritis in mice.

Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis

This study shows that atheroma plaque microenvironment activates the kynurenine pathway in macrophages, increasing kynurenine production which induces endothelial adhesion molecules, promoting atherogenesis.

Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein

The paper optimizes VHH antibodies targeting Tau's PHF6 peptide through mutagenesis and screening, showing improved binding and aggregation inhibition, but also highlighting the importance of stability beyond affinity.

Human Th17- and IgG3-associated autoimmunity induced by a translocating gut pathobiont

This study shows that the gut pathobiont Enterococcus gallinarum induces human Th17 and IgG3 autoantibody responses linked to disease activity in autoimmune patients.

Suppression of autoimmune arthritis and neuroinflammation via an amino acid-conjugatedbutyrate prodrug with enhanced oral bioavailability

This study develops a butyrate prodrug, SerBut, which improves oral bioavailability and reduces autoimmune arthritis and neuroinflammation in mouse models.

Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics

This study shows that conjugating immunogenic biologics to a synthetic mannose polymer reduces anti-drug antibody responses by impairing T cell and B cell responses.

Glycosylation-modified antigens as an inverse vaccine platform prevent anaphylaxis in a pre-clinical model of food allergy

This paper develops a glycosylation-modified antigen vaccine platform that prevents anaphylaxis in a cow's milk allergy mouse model by inducing antigen-specific non-responsiveness.

Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis

This study creates a mouse model with a selective knockout of the TLQP-21 neuropeptide, revealing its role in temperature-dependent resistance to diet-induced obesity and brown adipose tissue activation.

Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism.

The paper investigates the effects of LONP2 depletion on peroxisomal function and cholesterol metabolism, revealing cell-type-specific responses and implications for peroxisomal disorders.

A phage weaponizes a satellite recombinase to subvert viral restriction

The paper identifies a phage-encoded protein, Adi, that subverts a bacterial restriction system by repurposing a recombinase to enhance nuclease activity against the restriction element.

SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis

This study identifies MAPL's role in regulating bile acid synthesis and metabolic homeostasis, showing its loss leads to insulin sensitivity and hepatocellular carcinoma.

Evolutionary sweeps of subviral parasites and their phage host bring unique parasite variants and disappearance of a phage CRISPR-Cas system

The paper identifies new PLE variants in V. cholerae and links their spread to the loss of a CRISPR-Cas system in its phage host.

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity

This study develops a subunit nanovaccine using polymersomes decorated with SARS-CoV-2 RBD, showing enhanced neutralizing antibody and T cell responses in mice.

Macrophage Circadian Rhythms are Differentially Affected Based on Stimuli

This study examines how macrophage polarization and cancer cell-conditioned media affect circadian rhythms in macrophages and cancer cells, revealing distinct circadian characteristics based on phenotype.

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

This paper demonstrates that conjugating the SARS-CoV-2 Spike protein to a polymeric glyco-adjuvant elicits strong cellular and humoral immune responses in mice.

Nanotraps for the containment and clearance of SARS-CoV-2

This paper introduces Nanotraps, functionalized nanoparticles that block SARS-CoV-2 infection by inhibiting spike protein-ACE2 interaction and triggering macrophage-mediated viral clearance.

The Origin of Conductive-Pulse Sensing Inside a Nanopore and the Role of Electro-Hydrodynamics

This study investigates conductive-pulse sensing in nanopores, showing electroosmosis drives DNA events and generates conductive pulses through polarization effects, challenging the dominant counterion theory.

Reconstructing the lineage histories and differentiation trajectories of individual cancer cells in JAK2-mutant myeloproliferative neoplasms

This study reconstructs the lineage histories and differentiation trajectories of JAK2-mutant HSCs in MPN patients, finding the mutation occurs decades before diagnosis and drives exponential growth of mutated HSC populations.

Early life imprints the hierarchy of T cell clone sizes

This study shows that early life clonal expansions shape the long-term hierarchy of T cell clone sizes in humans, even after decades of aging.

Tetrahymena Poc5 is a transient basal body component that is important for basal body maturation

This study shows that Tetrahymena Poc5 is essential for basal body maturation, affecting both basal body production and ciliogenesis.

The short-term effect of residential home energy retrofits on indoor air quality and microbial exposure: a case-control study

This study examines how residential energy retrofits affect indoor air quality and microbial exposure by comparing weatherized and non-weatherized homes.

Are bivalves susceptible to domestication selection? Using starvation tolerance to test for potential trait changes in eastern oyster larvae

This study tests if domestication selection affects starvation tolerance in eastern oyster larvae by comparing wild and selectively bred lines.

The PMK-3 (p38) Mitochondrial Retrograde Response Functions in Intestinal Cells to Extend Life via the ESCRT Machinery.

This study identifies PMK-3 as a key regulator of life extension in C. elegans following mitochondrial ETC disruption, showing its reliance on ESCRT machinery for cellular signaling.

Ventriculo-arterial uncoupling is associated with VO2 dependency in cardiac surgical patients

This study examines the relationship between ventriculo-arterial coupling and oxygen consumption response in cardiac surgical patients, finding that uncoupling is associated with increased VO2.

Brief Freezing Steps Lead to Robust Immunofluorescence in Drosophila Larval Brains

The paper compares immunofluorescence techniques for Drosophila larval brains, finding that freezing improves staining without compromising structural integrity.

Cleanliness in context: reconciling hygiene with a modern microbial perspective

The paper redefines hygiene as actions reducing pathogen spread rather than microbial load, and suggests using health outcomes to resolve debates on hand drying methods.