Author

A. C. Tremain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:proteomics· 2 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Solanki· 3 shared A. T. Alpar· 3 shared E. A. Watkins· 3 shared M. Nguyen· 3 shared R. P. Wallace· 3 shared A. Mansurov· 2 shared B. Manicassamy· 2 shared D. S. Wilson· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

A. Solanki

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3 papers

Recent·Most cited

Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics

R. P. Wallace, K. C. Refvik, J. T. Antane, K. Brünggel, A. C. Tremain, M. R. Raczy, A. T. Alpar, M. Nguyen, A. Solanki, A. J. Slezak, E. A. Watkins, A. L. Lauterbach, D. S. Wilson, J. A. Hubbell

This study shows that conjugating immunogenic biologics to a synthetic mannose polymer reduces anti-drug antibody responses by impairing T cell and B cell responses.

bioRxiv · Apr 7, 2023Bioengineering

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity

L. R. Volpatti, R. P. Wallace, S. Cao, M. Raczy, R. Wang, L. T. Gray, A. T. Alpar, P. S. Briquez, N. Mitrousis, T. M. Marchell, M. S. Sasso, M. Nguyen, A. Mansurov, E. Budina, A. Solanki, , J. Hubbell

This study develops a subunit nanovaccine using polymersomes decorated with SARS-CoV-2 RBD, showing enhanced neutralizing antibody and T cell responses in mice.

ACS Central Science · Jul 21, 2021Peer-reviewedBioengineering

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

L. T. Gray, M. M. Raczy, P. S. Briquez, T. M. Marchell, A. T. Alpar, R. P. Wallace, L. R. Volpatti, M. S. Sasso, S. Cao, M. Nguyen, A. Mansurov, E. Budina, E. A. Watkins, A. Solanki, N. Mitrousis, , J. A. Hubbell

This paper demonstrates that conjugating the SARS-CoV-2 Spike protein to a polymeric glyco-adjuvant elicits strong cellular and humoral immune responses in mice.

bioRxiv · May 20, 2021Bioengineering