J. A. Hubbell

Engineered Flt3L Drives Tolerogenic State to Attenuate Anti-drug Antibody Responses

The paper describes a method using engineered Flt3L to induce a tolerogenic immune state, reducing anti-drug antibodies to a fungal enzyme.

LDL-Binding IL-10 Reduces Vascular Inflammation in Atherosclerotic Mice

This paper develops a targeted IL-10 therapy by fusing it with an LDL-binding antibody fragment, showing reduced vascular inflammation in atherosclerotic mice.

Suppression of autoimmune arthritis and neuroinflammation via an amino acid-conjugatedbutyrate prodrug with enhanced oral bioavailability

This study develops a butyrate prodrug, SerBut, which improves oral bioavailability and reduces autoimmune arthritis and neuroinflammation in mouse models.

Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics

This study shows that conjugating immunogenic biologics to a synthetic mannose polymer reduces anti-drug antibody responses by impairing T cell and B cell responses.

Glycosylation-modified antigens as an inverse vaccine platform prevent anaphylaxis in a pre-clinical model of food allergy

This paper develops a glycosylation-modified antigen vaccine platform that prevents anaphylaxis in a cow's milk allergy mouse model by inducing antigen-specific non-responsiveness.

Microbial metabolite butyrate-prodrug polymeric micelles demonstrate therapeutic efficacy in pre-clinical models of food allergy and colitis

The paper develops butyrate-prodrug polymeric micelles that restore gut barrier function and reduce inflammation in pre-clinical models of food allergy and colitis.

Blocking antibodies against integrin-a3, integrin-aM, and integrin-aMb2 de-differentiate myofibroblasts and reverse lung and kidney fibroses in a mouse model

Blocking antibodies against integrins-3, -M, and -Mβ2 reverse lung and kidney fibrosis in a mouse model by de-differentiating myofibroblasts.

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

This paper demonstrates that conjugating the SARS-CoV-2 Spike protein to a polymeric glyco-adjuvant elicits strong cellular and humoral immune responses in mice.

Laminin heparin-binding peptides promiscuously bind growth factors and enhance diabetic wound healing

This study shows laminin heparin-binding peptides bind growth factors and enhance diabetic wound healing by acting as GF reservoirs and cell scaffolds.