Axonal organelle buildup from loss of AP-4 complex function causes exacerbation of amyloid plaque pathology and gliosis in Alzheimers disease mouse model
A. Orlowski, J. Karippaparambil, J.-M. Paumier, S. Ghanta, E. Pallares, R. Chandran, D. Edmison, J. Tandukar, R. Gao, S. Gowrishankar
The paper shows that loss of AP-4 complex function causes axonal lysosome buildup, which worsens amyloid plaque pathology and gliosis in an Alzheimer's disease mouse model.
bioRxiv · Mar 31, 2024Cell Biology