R. Gao

A Conserved Inhibitory Interdomain Interaction Regulates DNA-binding Activities of Hybrid Two-component Systems in Bacteroides

The paper identifies a conserved inhibitory interdomain interaction in HTCSs that suppresses DNA-binding activity in Bacteroides until phosphorylation occurs.

Axonal organelle buildup from loss of AP-4 complex function causes exacerbation of amyloid plaque pathology and gliosis in Alzheimers disease mouse model

The paper shows that loss of AP-4 complex function causes axonal lysosome buildup, which worsens amyloid plaque pathology and gliosis in an Alzheimer's disease mouse model.

Subregion and sex differences in ethanol activation of cholinergic and glutamatergic cells in the mesopontine tegmentum

This study examines how ethanol affects cholinergic and glutamatergic neuron activation in the mesopontine tegmentum of male and female mice, revealing sex- and subregion-specific responses.

Immortalization and transformation of primary cells mediated by engineered ecDNAs

This paper describes a method to engineer large focal amplifications in primary cells using ecDNAs, showing they promote proliferation and transformation.

Liquid Transmission Electron Microscopy for Probing Collagen Biomineralization

This paper introduces liquid transmission electron microscopy to study collagen biomineralization in real-time, showing mineral particles transition to crystalline platelets aligned with collagen fibrils.

Gel-assisted mass spectrometry imaging

The paper introduces a method to enhance spatial resolution in MALDI-MSI without changing hardware, enabling subcellular-scale analysis.

Phage administration with repeated intravenous doses leads to faster phage clearance in mammalian hosts

This study evaluates phage clearance and host responses to repeated intravenous phage doses in rats and monkeys, finding faster clearance and immune activation with repeated administration.

Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

PI(3,5)P2 Controls the Signaling Activity of Class I PI3K

This study identifies PI(3,5)P2 as a regulator of Class I PI3K activity by interacting with its p85 subunit, revealing a feedback mechanism that impacts cancer and tissue repair.

Alcohol availability during withdrawal gates the impact of alcohol vapor exposure on responses to alcohol cues

This study shows that chronic intermittent ethanol exposure affects alcohol cue responses only when alcohol is available during withdrawal, with sex-specific differences in consumption and behavior.

Viral genome-capsid core senses host environments to prime RNA release

This study identifies how viral RNA interacts with coat proteins to sense host environments and trigger capsid disassembly in Turnip crinkle virus.

A marine fungus efficiently degrades polyethylene

This study isolates a marine fungus capable of efficiently degrading polyethylene, identifying degradation products and enzymes involved in the process.

Cryo-electron microscopy revealed TACAN is extensively and specifically associated with membrane lipids

The paper reveals TACAN is a homodimer with lipid-associated domains and suggests membrane lipids coordinate with the protein to sense mechanical signals.

No observable guide-RNA-independent off-target mutation induced by prime editor

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

A marine bacterial community that degrades poly(ethylene terephthalate) and polyethylene

This study identifies a marine bacterial community capable of degrading PET and PE, elucidates its degradation mechanisms, and demonstrates its potential for bioremediation.

Small molecules inhibit SARS-COV-2 induced aberrant inflammation and viral replication in mice by targeting S100A8/A9-TLR4 axis

Temporal Metabolic Characteristics and Transcriptomic Landscape of Islets and Liver Reveal Dynamic Pathophysiology and Interorgan Crosstalk in High-fat Diet-induced Diabetes

This study examines the temporal metabolic and transcriptomic changes in islets and liver of mice on high-fat diet, revealing dynamic pathophysiology and interorgan crosstalk in diabetes.

Intracellular accumulation and secretion of hydrophobin-enriched vesicles aid the rapid sporulation of molds

The paper investigates the role of hydrophobin-enriched vesicles in mold sporulation, showing their intracellular accumulation and secretion contribute to spore hydrophobicity and rapid sporulation.

State-selective Modulation of Heterotrimeric Gαs Signaling with Macrocyclic Peptides

This study identifies two macrocyclic peptides that selectively modulate active and inactive states of Gs, offering a new approach for developing state-dependent GTPase inhibitors.

Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

Compensatory guaiacyl lignin biosynthesis at the expense of syringyl lignin in 4CL1-knockout poplar

Knockout of 4CL1 in Populus reveals a 4CL5-dependent compensatory pathway for lignification with links to thiol redox balance and sulfur assimilation.

A highly homogeneous expansion microscopy polymer composed of tetrahedron-like monomers

This paper introduces a new expansion microscopy polymer with a more homogeneous network structure, achieving higher resolution and reduced spatial errors in imaging.

Mutant p53 Drives Clonal Hematopoiesis through Modulating Epigenetic Pathway

This study identifies mutant p53's role in promoting clonal hematopoiesis by modulating the EZH2-mediated epigenetic pathway.

Deep learning achieves super-resolution in fluorescence microscopy

This paper introduces a deep learning method that achieves super-resolution in fluorescence microscopy without requiring numerical models or parameter tuning, successfully resolving images with low numerical aperture lenses and diffraction-limited confocal microscopy.