J. ter Beek

Breaking Barriers: pCF10 Type 4 Secretion System relies on a self-regulating muramidase to modulate the cell wall

The paper reports the structure and function of PrgK, a component of the T4SS in pCF10, revealing its muramidase activity and self-regulating domains.

A distinctive family of L,D-transpeptidases catalyzing L-Ala-mDAP crosslinks in Alpha and Betaproteobacteria

This paper identifies and characterizes a novel LD-transpeptidase in Gluconobacter oxydans that forms 1,3-type crosslinks, revealing structural and functional differences from known transpeptidases.

In vitro reconstitution reveals membrane clustering and RNA recruitment by the enteroviral AAA+ ATPase 2C

This study reconstitutes the membrane clustering and RNA recruitment functions of the enteroviral 2C protein in vitro, revealing its roles in viral replication and challenging its helicase function.

Structural foundation for the role of enterococcal PrgB in conjugation, biofilm formation and virulence

The paper reports the structure of PrgB from Enterococcus faecalis and shows how specific domains affect conjugation, biofilm formation, and virulence.

Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing

The paper characterizes the structure and function of TraI from pKM101, revealing its conserved DNA processing mechanism across plasmids.

Enterococcal PrgA extends far outside the cell and provides surface exclusion to protect against unwanted conjugation

This paper reports the structure and function of Enterococcus faecalis PrgA, showing it extends outside the cell to provide surface exclusion and reduce plasmid uptake.