Author

J. Tkac

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Alvarez-Quilon· 1 shared A. Bertokova· 1 shared A. Bonneau Fortin· 1 shared A. Pinkeova· 1 shared A. Roulston· 1 shared A. Singhania· 1 shared A. Tomikova· 1 shared A. Veloso· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. Alvarez-Quilon

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2 papers

Recent·Most cited

Glycoprofiling of proteins as prostate cancer biomarkers: a multinational population study

J. Tkac, A. Pinkeova, A. Tomikova, A. Bertokova, E. Fabinyova, R. Bartova, E. Jane, S. Hroncekova, K.-D. Sievert, R. Sokol, M. Jirasko, R. Kucera, I. E. Eder, W. Horninger, H. Klocker, , T. Bertok

This study evaluates fPSA and ZA2G glycoprofiling as prostate cancer biomarkers using a multinational population study and finds fPSA glycoprofiling shows significant clinical potential.

bioRxiv · Jun 27, 2023Biochemistry

CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition

D. Gallo, J. T. F. Young, J. Fourtounis, G. Martino, A. Alvarez-Quilon, C. Bernier, N. M. Duffy, R. Papp, A. Roulston, R. Stocco, J. Szychowski, A. Veloso, H. Alam, P. S. Baruah, A. Bonneau Fortin, , D. Durocher

The paper identifies PKMYT1 as a therapeutic target for CCNE1-amplified cancers, showing that its inhibition leads to synthetic lethality and tumor regression in combination with gemcitabine.

bioRxiv · Apr 8, 2021Cancer Biology