Macrophages undergo necroptosis during severe influenza A infection and contribute to virus-associated cytokine storm
A. C. Ferreira, C. Q. Sacramento, F. S. Pereira-Dutra, N. Fintelman-Rodrigues, P. P. Silva, M. Mattos, C. S. de Freitas, A. Marttorelli, G. R. de Melo, M. C. Macedo, I. G. Azevedo-Quintanilha, A. S. Carlos, J. V. Emidio, C. C. Garcia, P. T. Bozza, , T. M. L. Souza
This study shows that IAV or HA induces necroptosis in macrophages, contributing to cytokine storm and lung injury, and that anti-TNF treatment prevents these effects.
bioRxiv · Apr 20, 2022 · PreprintImmunology