Author

J. W. Holmes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:rat· 3 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Organism:zebrafish· 1

Frequent Co-Authors

J. J. Saucerman· 2 shared W. J. Richardson· 2 shared B. YIN· 1 shared C. L. Grek· 1 shared E. McGowan· 1 shared F. Bustos· 1 shared G. Ghatnekar· 1 shared J. D. Rogers· 1 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBioengineering

J. J. Saucerman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Automated Spatially Targeted Optical Micro Proteomics (AutoSTOMP) 2.0 identifies proteins enriched within inflammatory lesions in tissue sections and human clinical biopsies.

B. YIN, L. R. Caggiano, R.-C. Li, E. McGowan, J. W. Holmes, S. E. Ewald

AutoSTOMP 2.0 identifies proteins in specific regions of tissue sections and biopsies, revealing inflammatory proteins in cardiac infarcts and IgG4+ lesions.

bioRxiv · Mar 19, 2021 · PreprintImmunology

A Rapid Electromechanical Model To Predict Reverse Remodeling Following Cardiac Resynchronization Therapy

P. J. A. Oomen, T.-K. N. Phung, K. C. Bilchick, J. W. Holmes

This study develops a computational model to predict reverse left ventricular remodeling after cardiac resynchronization therapy, showing that outcomes depend on lead location and ischemia, not just QRS duration improvement.

bioRxiv · Nov 16, 2020Bioengineering

Multiscale model of heart growth during pregnancy: Integrating mechanical and hormonal signaling

K. Yoshida, J. J. Saucerman, J. W. Holmes

This study develops a multiscale model of maternal heart growth during pregnancy, showing that progesterone levels in early gestation significantly contribute to cardiac growth.

bioRxiv · Sep 18, 2020Bioengineering

The Connexin 43 Carboxyl Terminal Mimetic Peptide alphaCT1 Prompts Differentiation of a Collagen Scar Matrix Resembling Unwounded Skin

J. Montgomery, W. J. Richardson, J. M. Rhett, F. Bustos, K. Degen, G. Ghatnekar, C. L. Grek, S. Marsh, L. J. Jourdan, J. W. Holmes, R. G. Gourdie

The paper investigates the effect of αCT1 peptide on scar matrix structure in human and animal models, finding that it reduces collagen fiber alignment and promotes a scar resembling unwounded skin.

bioRxiv · Jul 7, 2020Cell Biology

Mechano-Chemo Signaling Interactions Modulate Matrix Production by Cardiac Fibroblasts

J. D. Rogers, J. W. Holmes, J. J. Saucerman, W. J. Richardson

The paper investigates how mechanical stretch and biochemical agonists interact to regulate matrix metalloproteinase secretion by cardiac fibroblasts, revealing synergistic and antagonistic effects on protease expression.

bioRxiv · May 6, 2020Bioengineering