Author

J. W. Lough

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. A. Auchampach· 2 shared T. C. Wan· 2 shared X. Wang· 2 shared A. Lauth· 1 shared B. C. Smith· 1 shared K. Kulik· 1 shared K. R. Kulik· 1 shared Z. Qu· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersCell Biology

J. A. Auchampach

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2 papers

Recent·Most cited

Loss of Tip60-dependent H2A.Z acetylation reprogramscardiomyocyte identity toward a regenerative state.

X. Wang, K. Kulik, T. C. Wan, Z. Qu, J. W. Lough, J. A. Auchampach

This study shows that Tip60-dependent H2A.Z acetylation maintains cardiomyocyte differentiation, and its loss reprograms CMs toward a regenerative state by inducing dedifferentiation and metabolic shifts.

bioRxiv · Jan 11, 2024 · PreprintCell Biology

Mitigation of Injury from Myocardial Infarction by TH1834, an Inhibitor of the Acetyltransferase Tip60

X. Wang, T. C. Wan, K. R. Kulik, A. Lauth, B. C. Smith, J. W. Lough, J. A. Auchampach

This study shows that inhibiting Tip60 acetyltransferase with TH1834 improves cardiac function and reduces damage after myocardial infarction in mice.

bioRxiv · Nov 9, 2021 · PreprintPharmacology & Toxicology