Nuclear Localization of Argonaute is affected by Cell Density and May Relieve Repression by microRNAs
K. C. Johnson, A. Kilikevicius, C. Hofman, J. Hu, Y. Liu, S. Aguilar, C. Graswich, Y. Han, T. Wang, J. Wescott, R. A. Brekken, L. Peng, G. Karagkounis, D. R. Corey
This study shows that nuclear localization of AGO2 in HCT116 cells and human colon tumors can de-repress miRNA targets and enhance cell migration, influenced by cell density, miRNA biogenesis, and miRISC components.
bioRxiv · Jul 7, 2023Biochemistry