R. A. Brekken

Imaging of cellular dynamics in vitro and in situ: from a whole organism to sub-cellular imaging with self-driving, multi-scale microscopy

The paper introduces a self-driving, multi-resolution light-sheet microscope to simultaneously observe sub-cellular dynamics and whole organisms over extended periods, applying it to study development, cancer, and immune interactions in zebrafish.

Nuclear Localization of Argonaute is affected by Cell Density and May Relieve Repression by microRNAs

This study shows that nuclear localization of AGO2 in HCT116 cells and human colon tumors can de-repress miRNA targets and enhance cell migration, influenced by cell density, miRNA biogenesis, and miRISC components.

Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer

The paper identifies mesothelial cell-derived antigen-presenting CAFs in pancreatic cancer that induce regulatory T cells through antigen-specific interactions.

Pleiotrophin drives a pro-metastatic immune niche within the breast tumor microenvironment

This study identifies pleiotrophin as a driver of a pro-metastatic immune niche in breast cancer, showing its role in immune suppression and metastasis, and highlights its potential as a therapeutic target.

AXL-TBK1 driven nuclear AKT3 promotes metastasis

This study identifies AXL-TBK1-driven nuclear AKT3 as a driver of EMT and metastasis, showing that selective AKT3 inhibition reduces tumor progression in breast cancer.

PRSS2 stimulates tumor growth by remodeling the TME via repression of Tsp1

This study identifies PRSS2 as a factor that represses Tsp-1 in the tumor microenvironment by binding to LRP1, promoting tumor growth.

DDR1-INDUCED NEUTROPHIL EXTRACELLULAR TRAPS DRIVE PANCREATIC CANCER METASTASIS

This study shows DDR1 signaling in pancreatic cancer cells promotes metastasis by inducing CXCL5 production, which recruits neutrophils to form extracellular traps that facilitate cancer cell invasion.

AXL is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

This study identifies AXL as a key driver of cell plasticity and metastasis in pancreatic cancer using single-cell RNA sequencing and mouse models.

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

This study uses single-cell RNA sequencing to analyze cellular heterogeneity in mouse pancreatic ductal adenocarcinoma progression, identifying epithelial-to-mesenchymal transition, inflammatory macrophages, and fibroblast subtypes.

Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer

This study identifies TBK1 as a key driver of epithelial plasticity in KRAS-mutant pancreatic cancer, showing its role in tumor growth and metastasis through Axl-mediated activation.