Author

J. Wienands

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

C. Griesinger· 2 shared D. Sieme· 2 shared S. Becker· 2 shared A. Singh· 1 shared C. Zhu· 1 shared D. M. Reyes-Aguilar· 1 shared F. Dar· 1 shared H.-K. Choi· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

C. Griesinger

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3 papers

Recent·Most cited

Autoinhibition in the Signal Transducer CIN85 Modulates B Cell Activation

D. Sieme, M. Engelke, N. Rezaei-Ghaleh, S. Becker, J. Wienands, C. Griesinger

This study identifies an intramolecular SH3:PRM interaction in CIN85 that modulates its valency and phase separation, affecting B cell activation.

bioRxiv · Jul 31, 2023Biophysics

Quantitative description of the phase separation behavior of the multivalent SLP65-CIN85 complex

J. Maier, D. Sieme, L. E. Wong, F. Dar, J. Wienands, S. Becker, C. Griesinger

The paper quantifies SH3-PRM interactions in SLP65/CIN85 complexes and models their phase separation behavior using LASSI, revealing an intramolecular interaction.

bioRxiv · Jul 31, 2023Biophysics

Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome

H.-K. Choi, S. Travaglino, M. Munchhalfen, R. Gorg, Z. Zhong, J. Lyu, D. M. Reyes-Aguilar, J. Wienands, A. Singh, C. Zhu

This study shows that CD40-CD40L interactions form catch bonds that enhance B cell signaling and antibody class-switch, and mutations in CD40L disrupt this mechanism, causing X-linked Hyper IgM syndrome.

bioRxiv · Jul 23, 2023Immunology