Author

H.-K. Choi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Immunology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Zhu· 4 shared K. Li· 2 shared M. N. Rushdi· 2 shared Y. Zhang· 2 shared A. Grakoui· 1 shared A. M. Rosado· 1 shared A. Natarajan· 1 shared A. Singh· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersImmunology

C. Zhu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mechanotransduction governs CD40 function and underlies X-linked Hyper IgM syndrome

H.-K. Choi, S. Travaglino, M. Munchhalfen, R. Gorg, Z. Zhong, J. Lyu, D. M. Reyes-Aguilar, J. Wienands, A. Singh, C. Zhu

This study shows that CD40-CD40L interactions form catch bonds that enhance B cell signaling and antibody class-switch, and mutations in CD40L disrupt this mechanism, causing X-linked Hyper IgM syndrome.

bioRxiv · Jul 23, 2023Immunology

Memory in Repetitive Protein-Protein Interaction Series -- in Memory of the Late Professor Robert M. Nerem

A. M. Rosado, Y. Zhang, H.-K. Choi, S. M. Elrich, F. Jin, A. Grakoui, B. D. Evavold, C. Zhu

The paper analyzes memory effects in repetitive protein-protein interactions using experimental techniques and models, finding short- and intermediate-term memory in TCR-pMHC interactions.

bioRxiv · Oct 1, 2022 · PreprintBiophysics

Catch bond models may explain how force amplifies TCR signaling and antigen discrimination

H.-K. Choi, P. Cong, C. Ge, A. Natarajan, B. Liu, Y. Zhang, K. Li, M. N. Rushdi, W. Chen, J. Lou, M. Krogsgaard, C. Zhu

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.

bioRxiv · Jan 17, 2022Biophysics

Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity

M. N. Rushdi, V. Pan, K. Li, H.-K. Choi, S. Choi, J. Hong, F. Griffitts, P. Agnihotri, R. A. Mariuzza, Y. Ke, C. Zhu

The paper shows CD4 enhances TCR sensitivity by forming trimolecular bonds with pMHC, which are stabilized by force and proximity.

bioRxiv · Nov 22, 2021 · PreprintImmunology

Comparative transcriptome analysis reveals higher expression of stress and defense responsive genes in dwarf soybeans obtained from the crossing of G. max and G. soja

Y.-W. Ban, N. S. Roy, H. Yang, H.-K. Choi, J.-H. Kim, P. Basnet, K.-S. Ha, J.-K. Ham, K.-C. Park, I.-Y. Choi

The paper compares transcriptomes of normal and dwarf soybeans to identify differentially expressed genes related to stress, defense, and growth.

bioRxiv · Oct 29, 2018Plant Biology