Heat-inactivated modified vaccinia virus Ankara boosts Th1-biased cellular and humoral immune responses as a vaccine adjuvant by activating the STING-mediated cytosolic DNA-sensing pathway
N. Yang, A. Garzia, C. Meyer, T. Tuschl, T. Merghoub, J. Wolchok, L. Deng
This study shows heat-inactivated MVA enhances Th1 immune responses by activating the STING pathway and improves antitumor efficacy when combined with antigens.
bioRxiv · Jul 24, 2021 · PreprintImmunology