Author

A. Snyder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 2 Approach:benchmark study· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Ahuja· 2 shared B. A. Aksoy· 2 shared D. F. Bajorin· 2 shared J. Hammerbacher· 2 shared A. B. Reeve· 1 shared A. Gilson· 1 shared A. Jimenez-Sanchez· 1 shared A. Rubinsteyn· 1 shared

Activity by Year

2016-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCancer Biology

A. Ahuja

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

HIV-1 resistance to islatravir/tenofovir combination therapy in wild-type or NRTI resistant strains of diverse HIV-1 subtypes

M. A. Cilento, X. Wen, A. B. Reeve, A. Snyder, O. Ukah, C. M. Carrillo, C. P. Smith, K. Edwards, C. C. Wahoski, D. R. Kitzler, E. N. Kodama, H. Mitsuya, M. Parniak, P. R. Tedbury, S. G. Sarafianos

This study evaluates resistance to islatravir and tenofovir in HIV-1 strains with mutations K65R, M184V, and S68G/N, showing that their combination has a high genetic barrier to resistance.

bioRxiv · Jun 18, 2023 · PreprintMicrobiology

Unraveling Tumor-Immune Heterogeneity in Advanced Ovarian Cancer Uncovers Immunogenic Effect of Chemotherapy

A. Jimenez-Sanchez, P. Cybulska, K. Lavigne, T. Walther, I. Nikolovski, Y. Mazaheri, B. Weigelt, D. S. Chi, K. J. Park, T. Hollmann, D.-L. Couturier, A. Vargas, J. D. Brenton, E. Sala, A. Snyder, M. L. Miller

This study analyzes tumor-immune heterogeneity in ovarian cancer before and after chemotherapy, finding that chemotherapy increases cytotoxic immune activation in site-matched samples.

bioRxiv · Oct 17, 2018Cancer Biology

A Multifactorial Model of T Cell Expansion and Durable Clinical Benefit in Response to a PD-L1 Inhibitor

M. D. Leiserson, V. Syrgkanis, A. Gilson, M. Dudik, S. Gillett, J. Chayes, C. Borgs, D. F. Bajorin, J. Rosenberg, S. Funt, A. Snyder, L. Mackey

This paper develops a multifactorial model to predict T cell expansion and clinical benefit from PD-L1 inhibitors using clinical, tumor, and circulating features, showing improved accuracy over single biomarkers.

bioRxiv · Apr 10, 2018Cancer Biology

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

T. O'Donnell, E. L. Christie, A. Ahuja, J. Buros, B. A. Aksoy, D. D. L. Bowtell, A. Snyder, J. Hammerbacher

This study examines how chemotherapy affects neoantigen expression in ovarian cancer by analyzing mutational signatures and neoantigen burden in pre- and post-treatment samples.

BMC Cancer · Jan 22, 2018Peer-reviewedCancer Biology

Global Cancer Transcriptome Quantifies Repeat Element Polarization Between Immunotherapy Responsive and T cell Suppressive Classes

A. Solovyov, N. Vabret, K. S. Arora, A. Snyder, S. A. Funt, D. F. Bajorin, J. E. Rosenberg, N. Bhardwaj, D. T. Ting, B. D. Greenbaum

The paper quantifies repeat element polarization in cancer transcriptomes to identify biomarkers for immunotherapy response and tumor microenvironment immunosuppression.

bioRxiv · Jun 4, 2017Cancer Biology

Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade

T. Nathanson, A. Ahuja, A. Rubinsteyn, B. A. Aksoy, M. D. Hellmann, D. Miao, E. Van Allen, T. Merghoub, J. Wolchok, A. Snyder, J. Hammerbacher

The paper reanalyzes exome and RNA-Seq data from melanoma patients treated with CTLA-4 blockade to assess the predictive value of somatic mutation burden and neoepitope homology to pathogens.

bioRxiv · Nov 17, 2016Cancer Biology