B. A. Aksoy

The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner.

This study shows that varying levels of PI3Kδ pathway inhibition affect T cell stemness, with higher stemness improving cancer immunotherapy outcomes in multiple tumor models.

Discovering tumor-reactive T-cell receptors through single-cell sequencing of tumor-infiltrating lymphocytes

The paper uses single-cell sequencing of tumor-infiltrating lymphocytes to identify and validate novel tumor-reactive T-cell receptors in a mouse model.

Towards a scaled-up T cell-mediated cytotoxicity assay in 3D cell culture using microscopy

The paper develops a 3D cell culture system with microfluidics and automated widefield fluorescence microscopy to measure T cell-mediated cytotoxicity in tumor spheroids.

Viable and efficient electroporation-based genetic manipulation of unstimulated human T cells

This paper develops efficient electroporation protocols for genetic manipulation of unstimulated human T cells, enabling high-efficiency gene editing and expression with minimal cytotoxicity.

Computational and experimental optimization of T cell activation

The paper optimizes T cell activation by identifying key culture factors and uncovering artifacts in bead-based activation methods.

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

This study examines how chemotherapy affects neoantigen expression in ovarian cancer by analyzing mutational signatures and neoantigen burden in pre- and post-treatment samples.

PI3Kδ inhibition supports memory T cells with enhanced antitumor fitness

This paper shows that inhibiting PI3Kδ with CAL-101 enhances CD8+ T cell memory and antitumor efficacy in both murine and human models.

Somatic Mutations and Neoepitope Homology in Melanomas Treated with CTLA-4 Blockade

The paper reanalyzes exome and RNA-Seq data from melanoma patients treated with CTLA-4 blockade to assess the predictive value of somatic mutation burden and neoepitope homology to pathogens.