Comprehensive analysis of clustered mutations in cancer reveals recurrent APOBEC3 mutagenesis of ecDNA
E. N. Bergstrom, J.-C. Luebeck, M. Petljak, V. Bafna, P. S. Mischel, R. Harris, L. B. Alexandrov
The paper analyzes clustered mutations in 2,583 cancer genomes, identifying APOBEC3-driven mutagenesis on ecDNA as a significant contributor to cancer evolution.
bioRxiv · May 27, 2021Cancer Biology