Author

E. N. Bergstrom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:whole-genome sequencing· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

L. Alexandrov· 3 shared L. B. Alexandrov· 2 shared M. Petljak· 2 shared R. Harris· 2 shared A. Balmain· 1 shared A. Cristini· 1 shared A. Dananberg· 1 shared B. Otlu-Saritas· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCancer Biology

L. Alexandrov

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Author profile →

5 papers

Recent·Most cited

The interplay between dormant mutated cells and tumor promotion by chronic tissue damage in determining cancer risk.

Y. R. Li, E. Kandyba, K. Halliwill, R. Delrosario, Q. Tran, N. Bayani, D. Wu, O. Mirzoeva, M. M. Reeves, M. Islam, L. Riva, E. N. Bergstrom, K. Achanta, J. Digiovanni, L. Alexandrov, A. Balmain

This study analyzes mouse skin tumors to determine how environmental factors like TPA, obesity, and wounding affect mutational burden and cancer risk, finding that tumor promoters, not mutation number, limit tumor growth.

bioRxiv · Jan 24, 2024 · PreprintCancer Biology

Topography of mutational signatures in human cancer

B. Otlu-Saritas, M. Diaz-Gay, I. Vermes, E. N. Bergstrom, M. Zhivagui, M. Barnes, L. B. Alexandrov

This paper analyzes how mutational signatures in cancer genomes are influenced by genomic topography using integrated data from 5,120 tumors and ENCODE features.

bioRxiv · May 29, 2022Cancer Biology

R-loop homeostasis and cancer mutagenesis promoted by the DNA cytosine deaminase APOBEC3B

J. McCann, A. Cristini, E. Law, S. LEE, M. Tellier, M. Carpenter, C. Beghe, J. Kim, M. C. Jarvis, B. Stefanovska, N. A. Temiz, E. N. Bergstrom, D. Salamango, M. Brown, S. Murphy, , R. Harris

This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.

bioRxiv · Aug 30, 2021 · PreprintCancer Biology

Comprehensive analysis of clustered mutations in cancer reveals recurrent APOBEC3 mutagenesis of ecDNA

E. N. Bergstrom, J.-C. Luebeck, M. Petljak, V. Bafna, P. S. Mischel, R. Harris, L. B. Alexandrov

The paper analyzes clustered mutations in 2,583 cancer genomes, identifying APOBEC3-driven mutagenesis on ecDNA as a significant contributor to cancer evolution.

bioRxiv · May 27, 2021Cancer Biology

The APOBEC3A deaminase drives episodic mutagenesis in cancer cells

M. Petljak, K. Chu, A. Dananberg, E. N. Bergstrom, P. von Morgen, L. Alexandrov, M. R. Stratton, J. Maciejowski

This study shows that APOBEC3A drives episodic mutagenesis in cancer cells by reducing clustered mutations and identifying key enzymes involved in mutation generation.

bioRxiv · Feb 14, 2021 · PreprintCancer Biology