K. H. Lee

plantMASST - Community-driven chemotaxonomic digitization of plants

The paper curates LC-MS/MS data from plant extracts to create a taxonomically focused database for exploring plant-derived molecules.

A subtle modification of modafinil-based DAT inhibitors changes conformational preference

The paper investigates how a subtle structural change in modafinil analogs affects their binding to the dopamine transporter, revealing conformational differences between sulfoxide and sulfide substitutions.

The unseen invaders: tracking phylogeographic dynamics and genetic diversity of cryptic Pomacea canaliculata and P. maculata (Golden Apple Snails) across Taiwan

This study tracks the phylogeographic dynamics and genetic diversity of invasive golden apple snails in Taiwan to inform management strategies.

Linkers in bitopic agonists shape bias profile among transducers for the dopamine D2 and D3 receptors

The paper analyzes bitopic ligands for dopamine D2 and D3 receptors, showing that linker structure and stereochemistry significantly influence transducer bias profiles.

Unraveling activation-related rearrangements and intrinsic divergence from ligand-induced conformational changes of the dopamine D3 and D2 receptors

This study identifies activation-related conformational changes and intrinsic divergence in dopamine D2 and D3 receptors by analyzing structures and simulations, revealing ligand-induced conformational changes obscure key differences.

CD244 regulates both innate and adaptive immune axes in melanoma by inhibiting autophagy-mediated M1 macrophage maturation

This study shows CD244 inhibits macrophage maturation in melanoma, enhancing T cell responses and improving tumor rejection when combined with PD-L1 blockade.

Identification and Characterization of ML321: a Novel and Highly Selective D2 Dopamine Receptor Antagonist with Efficacy in Animal Models that Predict Atypical Antipsychotic Activity

This paper develops ML321, a highly selective D2 dopamine receptor antagonist, showing efficacy in animal models predictive of atypical antipsychotic activity with fewer side effects.

Unusual Morphological Changes of Rugositalea oryzae, A Novel Wrinkled Bacterium Isolated from The Rice Rhizosphere, Under Nutrient Stress

The paper describes a novel bacterial strain, Rugositalea oryzae, isolated from rice rhizosphere that exhibits morphological changes under nutrient stress.

Lung endothelium instructs dormancy of susceptible metastatic tumour cells

This study identifies endothelial-derived Wnt factors and tumor cell methylation status as key regulators of aCTC dormancy versus proliferation during metastasis.

Bacterial Infection of the Placenta Induces Sex-Specific Responses in the Fetal Brain

This study shows that placental infection with Listeria monocytogenes causes sex-specific gene expression changes and neurodevelopmental abnormalities in fetal brains, leading to distinct behavioral outcomes in male and female offspring.

Listeria monocytogenes Infection Alters Extracellular Vesicles Produced by Trophoblast Stem Cells to Confer a Pro-Inflammatory State

This study shows that Listeria monocytogenes infection alters trophoblast stem cell-derived extracellular vesicles, making macrophages pro-inflammatory and more susceptible to infection.

Ultramicrobacteria in various fermented cabbages

This study identifies ultramicrobacteria in fermented cabbages using advanced sequencing and microscopy, revealing their diversity and potential ecological significance.

Efficacy and gut dysbiosis of gentamicin-intercalated smectite as a new therapeutic agent against Helicobacter pylori in a mouse model

This paper evaluates a new gentamicin-intercalated smectite (S-GM) therapy for H. pylori in mice, showing comparable efficacy to standard triple therapy and reduced gut dysbiosis.

The Effect of New Nurses' Clinical Competence on Career Adaptation

This study examines how clinical competence affects career adaptability in new nurses, finding a positive correlation and identifying specific subcategories that influence adaptability.

Vaccination with single plasmid DNA encoding IL-12 and antigens of severe fever with thrombocytopenia syndrome virus elicits complete protection in IFNAR knockout mice

This paper develops a DNA vaccine encoding SFTSV antigens and adjuvants that provides complete protection in IFNAR knockout mice, while protein antigens alone fail to do so.

A ClyA nanopore tweezer for analysis of functional states of protein-ligand interactions

This paper demonstrates the use of a ClyA nanopore to monitor conformational changes of maltose-binding protein (MBP) in real time, revealing three distinct ligand-bound states corresponding to different reducing sugar isomers.

Lattice arrangement of myosin filaments correlates with fiber type in rat skeletal muscle

The paper uses X-ray diffraction and electron microscopy to show that rat soleus muscle has a simple thick filament lattice, while extensor digitorum longus has a super lattice, correlating with slow and fast fiber types respectively.

A stealth adhesion factor contributes to Vibrio vulnificus pathogenicity: Flp pili play roles in host invasion, survival in the blood stream and resistance to complement activation

This study shows that all three Tad operons in Vibrio vulnificus are required for pathogenicity, as they enable host invasion, survival in blood, and resistance to complement activation through Flp pili.

The central role of the tail in switching off myosin II in cells

The paper reveals the structural mechanism by which the tail of myosin II inhibits its activity by interacting with the heads to block ATP hydrolysis, actin binding, and filament formation.