Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis
M. C. Ludikhuize, M. Meerlo, M. Pages Gallego, M. Burgaya Julia, N. T. B. Nguyen, E. C. Brombacher, J.-H. Paik, B. M. T. Burgering, M. J. Rodriguez Colman
The paper shows that FOXO and Notch signaling regulate mitochondrial fission, driving intestinal stem cell differentiation into secretory lineages through metabolic rewiring.
bioRxiv · Sep 20, 2019Cell Biology