Cell BiologybioRxiv
Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis
M. C. Ludikhuize, M. Meerlo, M. Pages Gallego…·M. J. Rodriguez Colman
The paper shows that FOXO and Notch signaling regulate mitochondrial fission, driving intestinal stem cell differentiation into secretory lineages through metabolic rewiring.