Author

E. C. Brombacher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

B. Everts· 2 shared B. Guigas· 2 shared F. Otto· 2 shared T. A. Patente· 2 shared A. H. de Ru· 1 shared A. J. van der Ham· 1 shared A. Ozir-Fazalalikhan· 1 shared A. Zawistowska-Deniziak· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

B. Everts

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Author profile →

3 papers

Recent·Most cited

AMPK activation induces RALDHhigh tolerogenic dendritic cells through rewiring of glucose and lipid metabolism

E. C. Brombacher, T. A. Patente, A. J. van der Ham, T. J. A. Moll, F. Otto, F. W. M. Verheijen, E. A. Zaal, A. H. de Ru, R. T. N. Tjokrodirijo, C. R. Berkers, P. A. van Veelen, B. Guigas, B. Everts

This study shows that AMPK activation makes human dendritic cells more tolerogenic by altering their metabolism, specifically increasing RALDH activity and changing lipid and glucose metabolism.

bioRxiv · Jul 4, 2023 · PreprintImmunology

LKB1 signalling in dendritic cells controls whole-body metabolic homeostasis by limiting T helper 17 priming

H. J. P. van der Zande, E. C. Brombacher, J. M. Lambooij, L. R. Pelgrom, A. Zawistowska-Deniziak, T. A. Patente, G. A. Heieis, F. Otto, A. Ozir-Fazalalikhan, M. Yazdanbakhsh, B. Everts, B. Guigas

This study shows that LKB1 in dendritic cells limits T helper 17 cell priming, thereby protecting against obesity-induced metabolic dysfunctions.

bioRxiv · Oct 14, 2021 · PreprintImmunology

Mitochondria define intestinal stem cell differentiation downstream of a FOXO/Notch axis

M. C. Ludikhuize, M. Meerlo, M. Pages Gallego, M. Burgaya Julia, N. T. B. Nguyen, E. C. Brombacher, J.-H. Paik, B. M. T. Burgering, M. J. Rodriguez Colman

The paper shows that FOXO and Notch signaling regulate mitochondrial fission, driving intestinal stem cell differentiation into secretory lineages through metabolic rewiring.

bioRxiv · Sep 20, 2019Cell Biology